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The term cold
chain describes the network of fridges, freezers and cold boxes used for
transporting and storing vaccines within the safe temperature range of 2ºC -
8ºC (35.6ºF - 46.4ºF). Many
vaccines
can lose their potency and are rendered useless if they
get too hot, freeze, or are exposed to light. Vulnerability to heat or cold
varies depending on the type of vaccine. The loss of effectiveness is
cumulative and cannot be reversed.
The success of any immunization program depends on the cold chain to
keep vaccines at the proper temperature. It is essential
to maintain an unbroken cold chain for
vaccines from the point of manufacture until they are used.
Typical Cold Chain

(Source:
WHO Vaccines, Immunizations, and Biologicals)
Cold
chains in most low-income countries are in an advanced state of decay.
Old, kerosene-powered refrigerators
experience frequent downtimes due to lack of fuel and spare parts and
inappropriate transport containers can expose goods
to wide variations in temperature. As a result, temperature-sensitive
vaccines become spoiled, severely hampering efforts
to increase immunization rates in areas where infectious disease is a
persistent problem.
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